Structural genomics of “non-standard” proteins: a chance for membrane proteins?
نویسندگان
چکیده
منابع مشابه
Structural genomics plucks high-hanging membrane proteins.
Recent years have seen the establishment of structural genomics centers that explicitly target integral membrane proteins. Here, we review the advances in targeting these extremely high-hanging fruits of structural biology in high-throughput mode. We observe that the experimental determination of high-resolution structures of integral membrane proteins is increasingly successful both in terms o...
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The TSTMP database is designed to help the target selection of human transmembrane proteins for structural genomics projects and structure modeling studies. Currently, there are only 60 known 3D structures among the polytopic human transmembrane proteins and about a further 600 could be modeled using existing structures. Although there are a great number of human transmembrane protein structure...
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Structural genomics is a broad initiative of various centers aiming to provide complete coverage of protein structure space. Because it is not feasible to experimentally determine the structures of all proteins, it is generally agreed that the only viable strategy to achieve such coverage is to carefully select specific proteins (targets), determine their structure experimentally, and then use ...
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ژورنال
عنوان ژورنال: Gene Function & Disease
سال: 2002
ISSN: 1438-7506,1438-826X
DOI: 10.1002/1438-826x(200210)3:1/2<39::aid-gnfd39>3.0.co;2-6